Cities are the epicenter of challenges and opportunities in the 21st century. Regardless of the changing landscape brought about through executive and legislative changes at the federal level, local elected officials have the responsibility of ensuring that their residents and businesses thrive. They hold the ultimate responsibility for the well-being of all of their residents. Tackling challenging problems is the daily bread and butter of mayors and other city leaders. Harvard Law School-educated leaders held an interactive discussion about leading cities in times of great change.